Proteinase K

Proteinase K is a protease with serine as its active center. It has broad substrate specificity, and it preferentially decomposes the ester and peptide bonds of the C-terminus of hydrophobic amino acids, sulfur-containing amino acids and aromatic amino acids. It can degrade protein in a variety of different salts, denaturants, detergents, pH and temperature conditions. It’s mainly used for the digestion of proteins during the preparation of DNA and RNA.